Research | Therapies for Inherited Neuropathies

Creating a rapid drug discovery test for CMT1X

TIN has sponsored the laboratory of Mario Bortolozzi at the Veneto Institute of Molecular Medicine in a research project aimed at creating a “test in a dish for CMT1X”. This work aims to directly link genetic defects of CMT1X patients, with dysfunction of the...

Development of anti-human antibodies for the treatment of CMT1X

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The laboratories of Rudolf Martini and Richard Stanley have previously reported the discovery of a novel biological pathway in the human immune system, which is turned on in response to injury in the peripheral nervous system. A biological messenger that is produced...

Physical Exercise as a possible Therapy for CMT1X

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New Physical Exercise study published in November, 2024 issue of the Journal of the Peripheral Nervous System The results of a TIN-sponsored study to determine the effects of exercise on the progression of CMT1X, using a mouse model of CMT1X, was first published as...

An immune modulatory off-label approach for treating CMT1X

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An immune modulatory off-label approach for treating CMT1X The Martini laboratory has also initiated a program of evaluating drugs approved for other diseases for their possible use in treating CMT. The principle being followed is that drugs with demonstrated positive...