Research | Therapies for Inherited Neuropathies

Creating a rapid drug discovery test for CMT1X

TIN has recently engaged the laboratory of Mario Bortolozzi at the Veneto Institute of Molecular Medicine in a new sponsored research project. This project is aimed at directly linking genetic defects of CMT1X patients, with dysfunction of the protein that is produced...

Development of anti-human antibodies for the treatment of CMT1X

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The laboratories of Rudolf Martini and Richard Stanley have previously reported the discovery of a novel biological pathway in the human immune system, which is turned on in response to injury in the peripheral nervous system. A biological messenger that is produced...

Physical Exercise as a possible Therapy for CMT1X

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Physical Exercise study published in September issue of Experimental Neurology. The results of a TIN-sponsored study to determine the effects of exercise on the progression of CMT1X, using a mouse model of CMT1X, have now been published as the cover article in the...

An immune modulatory off-label approach for treating CMT1X

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An immune modulatory off-label approach for treating CMT1X The Martini laboratory has also initiated a program of evaluating drugs approved for other diseases for their possible use in treating CMT. The principle being followed is that drugs with demonstrated positive...