New Physical Exercise study published in November, 2024 issue of the Journal of the Peripheral Nervous System
The results of a TIN-sponsored study to determine the effects of exercise on the progression of CMT1X, using a mouse model of CMT1X, was first published as the cover article in the September 2021 issue of Experimental Neurology.
The article described a study employing CMT1X mice in which exercise was demonstrated to improve measures used as clinical outcomes in CMT patients, most notably effects on mobility, balance and pathology (progressive nerve damage). A description of this study, and a link to the article, can be found here.
An extension of this study has now been published in the November, 2024 issue of the Journal of the Peripheral Nervous System.
In this follow-on to the original study, the investigators investigated the clinical and histopathological effect of late-onset exercise in CMT1X mice at an advanced disease stage. The research team concluded that exercise has robust beneficial effects on nerve function in these mice, even when applied at a progressed disease stage and advanced age.
These results have important translational implications, suggesting that physical exercise might be an effective treatment option for CMT1 patients, even when disease symptoms have already progressed.
Physical exercise halts further functional decline in an animal model for Charcot–Marie–Tooth disease 1X at an advanced disease stage – Klein – Journal of the Peripheral Nervous System – Wiley Online Library